Biology of Thymic Tumors

Completed

• Conditions: Thymoma

• Registration Number: NCT00965627
• Lead Sponsor: Istituto Clinico Humanitas

Brief Summary

This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.

Detailed Description

The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.

Study Timeline

• Study Start: 2008-06
• Primary Completion: 2008-08
• Status Verified: 2009-08
• Study Completion: 2009-08
• Study First Submitted: 2009-08-06
• Study First Submitted QC: 2009-08-24
• Study First Posted: 2009-08-25
• Last Update Submitted: 2009-08-27
• Last Update Posted: 2009-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 134

Inclusion Criteria

• Availability of tumor tissue and patients with thymoma and thymic carcinoma

Exclusion Criteria

• NON Availability of tumor tissue and patients with thymoma and thymic carcinoma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.	one year

Secondary Outcome Measures

Name	Time	Method
Secondary objective: to correlate the biological characteristics with clinical characteristics and survival data of patients.	one year

Trial Locations

Locations (1)

Istituto Clinico Humanitas; 🇮🇹 Rozzano, Milano, Italy