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Clinical Trials/NCT07261761
NCT07261761
Completed
Not Applicable

Cytokines as Diagnostic Markers of Pulpal Inflammation and Their Impact on the Outcome of Vital Pulp Therapy

Mansoura University1 site in 1 country40 target enrollmentStarted: October 1, 2022Last updated:
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Overview

Phase
Not Applicable
Status
Completed
Enrollment
40
Locations
1
Primary Endpoint
Clinical success
OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Overview

Brief Summary

intervention eligible patients with teeth diagnosed with reversible or irreversible pulpits will go for vital pulp therapy and the other group will be patients will go for extraction of caries free teeth for orthodontic reasons, blood samples will be collected from both groups to analyze the level of cytokines IL-8 and IL-10 and it's relation with the success of the pulp therapy

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
16 Years to 45 Years (Child, Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •The age ranges from 16-45 years medically free.
  • •Tooth should be vital on cold testing.
  • •Vital permanent premolar and molar on cold testing, with deep caries, subsequent pulp exposure and bleeding pulp tissue in all canals after complete pulpotomy.
  • •Diagnosis is either reversible or irreversible pulpitis with/ without periapical rarefaction.
  • •The tooth is restorable and free from advanced periodontal disease.
  • •Soft tissues around the tooth are normal with no swelling or sinus tract.

Exclusion Criteria

  • •Patients over 45 years of age.
  • •Patients with clinical symptoms of periradicular inflammation or any periradicular radiographic lesions.
  • •Negative results for cold and electrical pulp testing

Outcomes

Primary Outcomes

Clinical success

Time Frame: one day, one, four and twelve weeks.

post operative pain on cold testing binary outcome (Yes or no)

Secondary Outcomes

  • Radiographic success(Pre-operative , and after six months)
  • level of cytokines(through study completion, an average of 6 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Mohamed Khalifa

Researcher at faculty of dentistry Mansoura University

Mansoura University

Study Sites (1)

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