Comparison of the effect of two drugs Alloprinol and Aminophylline in the treatment of neonates with asphyxia
Phase 3
- Conditions
- AsphyxiaR09.01Asphyxia.
- Registration Number
- IRCT20121229011923N7
- Lead Sponsor
- Faculty of Medical Sciences Shoushtar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
5 minute apgar less than 5
The pH of the cord artery is less than
Exclusion Criteria
Parental dissatisfaction
Premature infants with congenital and chromosomal abnormalities and renal and abdominal malformations
Mother with gestational diabetes
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improve kidney function. Timepoint: To evaluate the performance of all BUN, Cr and electrolyte measurements (Na and k) one day in between for one week. Method of measurement: Blood test.;Improve brain function. Timepoint: Daily. Method of measurement: The nervous system is also monitored daily by Moro, sucking, Grasping reflexes and the DTR index (deep tendon reflex). And if they are normal, we move one shot at a time, and we have the same direction with the muscle that we hit. Depending on the reflex we can score 4 (score 0): Under no circumstances can reflex be achieved, (+1 score): We can get reflex when the patient is distracted and reflex is reduced (+2 score) : The reflex is normal, (+3 score) when we have expansion at the point of insertion (reflex can also be achieved at other locations), (+4 score): when clonus This means that when a blow is made, the reflex is repeated several times, and the movement is repeated several times, with a score of 0 or 4 and 3 meaning a brain injury.
- Secondary Outcome Measures
Name Time Method