Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 194
- 试验地点
- 1
- 主要终点
- ICU Days
研究概览
简要总结
We hypothesize that serial changes of body composition in patients with pneumonia can help clinician to monitor prognosis. It was associated with underlying immune response.
详细描述
Specific aims:
- Can serial body composition data be useful for predicting outcomes of patients with pneumonia? (developing sepsis, organ failure, admission to ICU, length of ICU, survival, length of stay in hospital, prolonged mechanical ventilation,..)
- Can serial body composition data be integrated into both immune status alternatives (e.g., white blood cell (WBC) count, segment/monocyte ratio, pulse pressure) in such critical illness and monitoring responses (SOFA score, labs) for severe pneumonia patients?
- Can serial body composition data reflect clinical variables in patients with pneumonia, and even altered by nutrition intake? (e.g., compare association between nutrition intake amount and groups stratified by body composition, blood pressure, nutritional intake, ...)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with pneumonia admitted to the thoracic ward or medical intensive care unit of Kaohsiung Chang Gung Memorial Hospital
排除标准
- 未提供
结局指标
主要结局
ICU Days
时间窗: During hospitalization， "through study completion, an average of 1 year"
length of stay in ICU
Ventilation days
时间窗: up to 24 weeks
days of mechanical ventilation
Change in segment/monocyte ratio
时间窗: Change from Baseline Segment count to monocyte count ratio at day 8
Change in Segment count to monocyte count ratio
sepsis free days
时间窗: up to 24 weeks
the cure day of sepsis
mortality
时间窗: During hospitalization， "through study completion, an average of 1 year"
death rate
Change in Total Body Water
时间窗: Change from Baseline Total Body Water at day 8
Change in Total Body Water
Change in Percentage of Body Fat
时间窗: Change from Baseline Percentage of Body Fat at day 8
Change in Percentage of Body Fat
Change in Soft Lean Mass
时间窗: Change from Baseline Soft Lean Mass at day 8
Change in Soft Lean Mass
次要结局
未报告次要终点