NL-OMON28309
Completed
Not Applicable
A randomised, double blind, parallel, placebo controlled, drug-drug interaction study to investigate the safety, tolerability and pharmacokinetics of multiple doses of HTL0018318 given alone and in combination with donepezil at steady state in elderly volunteers.
Heptares Therapeutics Ltd.0 sites36 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Drug-Drug interaction, M1 agonist, Alzheimer, donepezil
- Sponsor
- Heptares Therapeutics Ltd.
- Enrollment
- 36
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
ot applicable
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Elderly male or female subjects aged between 65 and 80 (inclusive) years old;
- •2\. Healthy subjects as defined by the absence of evidence of any active or chronic disease following detailed medical and surgical history review and a complete physical examination including vital signs, 12\-lead ECG, haematology, blood chemistry, and urinalysis;
Exclusion Criteria
- •Subjects must meet none of the following exclusion criteria at screening:
- •1\. Legal incapacity or inability to understand or comply with the requirements of the study.
Outcomes
Primary Outcomes
Not specified
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