The Gut Microbiome in Chronic Heart Failure

Not Applicable

Recruiting

• Conditions: Heart Failure

• Registration Number: NCT06573892
• Lead Sponsor: Nazarbayev University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-8-1
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Age over 18 years<br><br> - Residing in the city of Astana and surrounding regions (Akmola region)<br><br> - Diagnosis of heart failure according to internationally recognized guidelines and<br> classified as Class I-IV by NYHA (New York Heart Association) or Stage A-C according<br> to ACC/AHA (American College of Cardiology/American Heart Association)<br> classification<br><br> - Clinically stable condition and optimized medication therapy for heart failure for<br> at least 4 weeks in accordance with current recommendations<br><br> - Willingness to participate in the study<br><br>Exclusion Criteria:<br><br> - • Age under 18 years<br><br> - Refusal to undergo diagnostic procedures specified in the study protocol<br><br> - Terminal stage of heart failure (Stage D according to ACC/AHA classification)<br><br> - Coronary or peripheral revascularization procedures, valvular procedures, or<br> any major surgical procedure within 3 months prior to study enrollment<br><br> - Use of antibiotics, cytostatic therapy, or pro- or prebiotics within 1 month<br> prior to the baseline visit<br><br> - Presence of oncological and autoimmune diseases (connective tissue diseases,<br> gastrointestinal disorders, skin disorders, etc.)<br><br> - Acute illness or active infection<br><br> - Individual intolerance to the administered nutrients (probiotics)<br><br> - Presence of other anatomical or comorbid conditions, or other medical, social,<br> or psychological conditions that, in the investigator's opinion, may limit the<br> subject's ability to participate in the clinical study, comply with the<br> requirements of subsequent follow-up, or affect the scientific validity of the<br> clinical study results.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gut microbiome

Secondary Outcome Measures

Name	Time	Method
Frequency of hospitalizations