Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .

Not Applicable

Completed

• Conditions: Intraoperative Blood Loss
• Interventions: Drug: Oxytocin

• Registration Number: NCT06889155
• Lead Sponsor: Cairo University

Brief Summary

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Detailed Description

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Study Timeline

• Study Start: 2023-08-30
• Primary Completion: 2024-05-27
• Study Completion: 2024-09-14
• Status Verified: 2025-03
• Study First Submitted: 2025-03-17
• Study First Submitted QC: 2025-03-17
• Last Update Submitted: 2025-03-17
• Study First Posted: 2025-03-21
• Last Update Posted: 2025-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

• Age 18 - 40 years
• singleton full term pregnancy.
• Candidate for elective cesarean delivery under spinal anaesthesia

Exclusion Criteria

• women at high risk for intraoperative bleeding as those with placenta previa or other placental abnormalities
• women with bleeding or coagulation disorders.
• Medical disorder associating pregnancy as preeclampsia or diabetes
• Allergy or contraindications to oxytocin
• Fetal macrosomia, or congenital anomalies
• Polyhydramnios
• Uterine abnormalities as fibroids
• Women with intraoperative complications as vascular or visceral injuries

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oxytocin before placental delivery	Oxytocin	oxytocin infusion before placental delivery just after cord clamping 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.
oxytocin after placental delivery	Oxytocin	oxytocin infusion after placental delivery 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Primary Outcome Measures

Name	Time	Method
Intraoperative blood loss	during cesarean delivery	This was measured by weighing the surgical sponges and the suction canisters used during the procedure

Trial Locations

Locations (1)

Armed force faculty of medicine; 🇪🇬 Cairo, Egypt