Comparison of two prophylactic antibiotic regimens (cefazolin and cefazolin+gentamicin) on surgical wound infection of CABG patients
Phase 2
- Conditions
- Prophylactic antibiotic.Prophylactic antibiotic therapy
- Registration Number
- IRCT201201114365N10
- Lead Sponsor
- Vice chancellor for research of Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Inclusion criteria are informed written consent; Age between 40 and 75 years; Elective CABG surgery; Use of the cardiopulmonary pump during surgery.
Exclusion criteria are history of infectious disease and use of antibiotic during previous week; Renal failure (baseline serum creatinine > 2mg/dl); systemic disease and drugs causing immunosuppression; together with other cardiac surgery (valvular surgery); Reoperation; Ejection fraction < 35%; history of sensitivity to cephalosporin or Gentamicin.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Surgical wound infection. Timepoint: 3, 7, 21 and 30 days after cardiac surgery. Method of measurement: observation - culture.
- Secondary Outcome Measures
Name Time Method Creatinine. Timepoint: 2 -4 days after surgery. Method of measurement: Laboratory kit - mg/dl.