Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients

Not Applicable

Completed

• Conditions: Stroke; Muscle Fatigue; Spasticity, Muscle; Gait, Hemiplegic
• Interventions: Procedure: Muscle fatigue

• Registration Number: NCT03342820
• Lead Sponsor: University Hospital, Lille

Brief Summary

This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients.

The effect of such a protocol on gait parameters and spasticity of the quadriceps will be evaluated also.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-16
• Study First Submitted QC: 2017-11-14
• Study First Posted: 2017-11-17
• Study Start: 2018-01-19
• Primary Completion: 2019-10-10
• Study Completion: 2019-10-10
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-25
• Last Update Posted: 2020-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age between 18 and 80y
• Hemiparesis after a first-ever stroke > 3 months
• Spasticity of the quadriceps muscle
• Quadriceps strength at least at 3/5 (MRC testing)
• Subject able to walk at least 2min without rest
• Informed consent
• Social security affiliation

Exclusion Criteria

• Severe comprehension troubles (language, cognitive or psychiatric disorders)
• History of previous stroke, locomotor or other neurological disorders
• Locomotor troubles affecting the paretic arm
• Contraindication to efforts : cardiac insufficiency, severe aortic valvular stenosis, recent heart failure, non treated high blood pressure, severe peripheral arterial disease
• Pregnancy or breastfeeding
• Adult subject to guardianship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Quadriceps muscle fatigue	Muscle fatigue	Quadriceps muscle fatigue

Primary Outcome Measures

Name	Time	Method
Cocontraction Index (CCI) between the rectus femoris and the semitendinosus	one day	ratio of the RMS of a the rectus femoris when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG

Secondary Outcome Measures

Name	Time	Method
perceived exertion at the end of the 2MWT (Borg Scale 6-20)	one day
10 metre walk test (10MWT)	one day	Assessment of max gait speed
Isometric peak knee flexion torque	one day	Isometric peak knee flexion torque assessed by a CONTREX dynamometer
spatio-temporal gait parameters at comfortable speed	one day	Step length
Cocontraction Index (CCI) between the other parts of the quadriceps and the semitendinosus muscle	one day	ratio of the RMS of a the vastus medialis, lateralis and intermedius when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG
Spasticity of the quadriceps	one day	Tardieu scale angle
2 minute walk test (2MWT)	one day	Assessment of max walking endurance
Agonist Recruitment Index of the semitendinosus	one day	ratio of the RMS of a muscle acting as an agonist during a given period to its largest RMS value observed during the 500 ms around its agonist recruitment peak
Isometric peak knee extension torque	one day	Isometric peak knee extension torque assessed by a CONTREX dynamometer

Trial Locations

Locations (1)

Hôpital Swynghedauw, CHU; 🇫🇷 Lille, France