Systeembiologische aanpak van de oorzaken en onderlinge verbanden van kenmerken van het metabool syndroom
Completed
- Conditions
- metabolic syndrome, insulin resistance, dyslipidemia, gastric bypass
- Registration Number
- NL-OMON29668
- Lead Sponsor
- Academic Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
scheduled for bariatric surgery (Roux-en-Y gastric bypass)
- 18-65 years of age
Exclusion Criteria
- use of exogenous insulin, GLP-1 agonists or DPP-4 inhibitors
- all medica! and psychiatric conditions except for obesity-related diseases
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - tissue gene expression in relation to glucose/lipid/lipoprotein fluxes
- Secondary Outcome Measures
Name Time Method - liver fat in relation to liver gene expression profiles and metabolic fluxes<br /><br>- parasympathetic/sympathetic balance and energy expenditure<br /><br>- gut microbiota composition in relation to metabolic fluxes<br /><br>- fructose tolerance