Inclusive physiological assessment: impact of location of flow velocity assessment

• Conditions: atherosclerosis; Coronary artery Disease; 10011082

• Registration Number: NL-OMON50864
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

* Age > 18 years
* Presentation with chronic coronary syndrome (Canadian Cardiovascular Society
(CCS) Class I-III)
* At least one epicardial stenosis in a native coronary artery with a clinical
indication for physiological measurements to inform decision-making.
* Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria

* Left main involvement requiring revascularization, ostial lesions, tandem
stenosis.
* Prior CABG to target vessel.
* Extremely tortuous or calcified coronary arteries precluding intracoronary
physiologic measurements.
* Visible collateral flow to the target vessel
* Recent (within 3 weeks prior to cardiac catheterization) ST-segment elevation
myocardial infarction (STEMI) in any arterial distribution (not specifically
target lesion).
* Renal failure (MDRD calculated eGFR of <30).
* Pregnancy.
* Severe valvular abnormalities that require surgery
* Severely impaired left ventricular (LV) function (ejection fraction < 30%)
* Known severe LV hypertrophy (> 13 mm septal wall thickness) Inability to sign
an informed consent, due to any mental condition that renders the subject
unable to understand the nature, scope, and possible consequences of the trial
or due to mental retardation or language barrier.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified