Assessment of the pathophysioLogical bAsis of local tissue compliaNce using augmenteD iMAging techniques to identify Regional flow dynamiCs (LANDMARC): a study with focus on aorta ascendens

Recruiting

• Conditions: aortic aneurysm; aortic dissection; 10002363

• Registration Number: NL-OMON53960
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 65

Inclusion Criteria

Patients who underwent open heart surgery and have participated in FIBAA-bank.

Exclusion Criteria

- Patients with abnormal congenital cardiothoracic anatomy, with exception of
presence of a bicuspid aortic valve
- Patients with history of chemotherapy, or radiotherapy within thoracic region
- Patients with an age >80 years
- Patients with a weight >120 kg
- Patients with a contra-indication for MRI according to the MUMC+ ODIN
protocol nr. 004952
- Patients with impaired renal function (GFR <30)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Association between the advanced multimodality imaging parameter WSS (peak<br /><br>WSS and WSS gradient) and (ascending) aortic strain. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Association between aortic elongation/aortic strain and degree of<br /><br>cardiovascular tissue fibrosis. </p><br>