Deep Versus Moderate Neuromuscular Blocks on Remifentanil Requirements in Patients Undergoing Surgical Pleth Index-guided Analgesia for Laparoscopic Gastrectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- total dose of remifentanil
研究概览
简要总结
The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of gastric cancer Scheduled laparoscopic gastrectomy
排除标准
- •Patients refusal to consent Hyperbilirubinemia Chronic pain Opioid abuse Incurrent infective status Peripheral vascular disease
研究组 & 干预措施
Moderate NMB group
maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg
干预措施: Neostigmine + glycopyrate (Drug)
Deep NMB group
maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 2~4 mg/kg
干预措施: Sugammadex (Drug)
结局指标
主要结局
total dose of remifentanil
时间窗: from pneumoperitoneum to removal of laparoscope
remifentanil infusion using target effect-site concentration to achieve an surgical pleth index of range between 20 and 50
次要结局
未报告次要终点
研究者
Ji Eun Kim
Assistant professor
Ajou University School of Medicine