Transplantation of umbilical cord blood (UCB) from unrelated donors (URD) in patients with haematological diseases using a reduced intensity conditioning regimen. - RIC UCBT (Cord Blood)

Phase 1

• Conditions: Haematological disorders; MedDRA version: 14.1Level: HLTClassification code 10018847Term: Haematological disordersSystem Organ Class: 100000004851

• Registration Number: EUCTR2004-003845-41-GB
• Lead Sponsor: niversity College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-01-16
• Last Update Posted: 20 July 2020

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1) Age 60 years or younger and 2 years or older. 2) Umbilical cord blood graft available with an adequate cell dose and HLA match. 3) Disease for which an allogeneic haemopoietic stem cell transplant (HSCT) is indicated. 4) Adequate organ function.
Are the trial subjects under 18? yes
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

1) Availability of a conventional related or unrelated haemopoietic stem cell donor. 2) Current active serious infection. 3) Previous irradiation that precludes the safe administration of an additional dose of 200 cGy of total body irradiation (TBI). 4) Refractory malignant disease. 5) Myelofibrosis

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified