CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection

Not Applicable

Recruiting

• Conditions: Cirrhosis, Liver; Hepatocellular Carcinoma

• Registration Number: NCT05433467
• Lead Sponsor: Northern Jiangsu People's Hospital

Brief Summary

In this project, the preoperative anatomical location of micro hepatocellular carcinoma under the guidance of CT can provide guidance for accurate surgical resection. It may also shorten the operation time and reduce intraoperative bleeding.

Detailed Description

General and basic information of the patients included in the study was collected. After preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle.

Study Timeline

• Study Start: 2022-05-01
• Study First Submitted: 2022-06-21
• Study First Submitted QC: 2022-06-21
• Study First Posted: 2022-06-27
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-28
• Last Update Posted: 2024-07-30
• Primary Completion: 2025-04-30
• Study Completion: 2025-04-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

1. Be at least 18 years old and give informed consent to participate in the study
2. A preoperative (clinical, radiological, or histological) diagnosis of cirrhosis of the liver due to any cause.
3. micro hepatocellular carcinoma (diameter less than 1cm).
4. Preoperative CT plain scan could not find the lesion, and preoperative B-ultrasound could not find the lesion.
5. Preoperative CT enhancement or MRI can detect the lesion.

Exclusion Criteria

1. Child-Pugh grade C
2. Uncontrolled Hypertension
3. Severe lung dysfunction
4. Severe cardiac dysfunction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
The position of the needle	During operation	The distance (mm) of the needle to the edge of hepatocellular carcinoma

Secondary Outcome Measures

Name	Time	Method
Operation time	During operation	The length of operation time (min)
Intraoperative bleeding	During operation	The volume of intraoperative bleeding (ml)

Trial Locations

Locations (1)

Clinical Medical College, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China