Effects of Perioperative Administration of Intravenous Lidocaine in Children Operated on for Acute Generalized Peritonitis
Not Applicable
Not yet recruiting
- Conditions
- Postoperative Pain
- Interventions
- Drug: Serum saline intravenous
- Registration Number
- NCT06051630
- Lead Sponsor
- Université NAZI BONI
- Brief Summary
Intravenous administration of lidocaine perioperatively after laparotomy for peritonitis could be an interesting alternative by reducing the duration of postoperative ileus, the intensity of pain and the patient's hospital stay, as well as the cost of management in our context of lack of financial, technical and human resources, hence the present study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- All patients aged 6 to 15, Classified according to the American Society of Anaesthesiologists (ASA) (I, II and III) admitted for peritonitis and whose parents have given informed consent
Exclusion Criteria
- State of shock
- Severe renal insufficiency (creatinine clearance less than 30 ml/min)
- History of allergy to lidocaine
- Refusal to participate in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Lidocaine group Lidocaine intravenous The group will receive 1.5 mg/kg lidocaine 2% bolus, followed by a continuous electric syringe dose of 1.5 mg/kg/hour intraoperatively, then 1.5 mg/kg/hour during the first 24 hours postoperatively Saline group Serum saline intravenous The control group will receive an equivalent volume of saline: the volume of saline to be administered will be obtained by considering the dose of lidocaine 2% that the patient would have received if he/she had been in the interventional group.
- Primary Outcome Measures
Name Time Method Resumption of transit Up to 7 days during the postoperative period. From the date of randomization to the first postoperative gas and/or the presence of postoperative bowel sounds in the patient time to first gas and/or presence of bowel sounds
- Secondary Outcome Measures
Name Time Method Analog visual scale Postoperative pain scores at 24 hours Average pain score, minimal value is 0, maximal value is 10 and higher score mean worse
Postoperative mortality Up to 30 days during the postoperative period. From date of randomization to date of death Number of postoperative deaths
Hospitalisation Up to 30 days during the postoperative period. From the date of randomization to the patient's discharge from hospital or date of death Number of days in hospital
Concentration of C-reactive protein Hours 24 postoperative Average of C-reactive protein