Sleep State Misperception Mispercieved?

Conditions: Paradoxical insomnia
10040998
Sleep state misperception
10040991

Registration Number: NL-OMON35484

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 36

Inclusion Criteria

Diagnosis of primary insomnia
20-70 years old
informed consent

Exclusion Criteria

psychotropic medication (exclusion if not at least 4 weeks off medication)
metal in body
severe claustrophobia
major somatic disorder
psychiatric disorder

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This project will apply analysis tools for ERP, functional connectivity for<br /><br>resting state EEG, resting state fMRI and task-related fMRI, single and double<br /><br>pulse TMS (no repetitive TMS).<br /><br>Main study parameter is the pattern of neural synchronization as measured using<br /><br>EEG (sleep & wake)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In addition we will determine<br /><br>-patterns of power spectra topography as measured using EEG (sleep & wake).<br /><br>-Subjective to objective sleep duration discrepancy as measured using sleep<br /><br>logs, actigraphy and EEG.<br /><br>-ERP latency and amplitude (topography).<br /><br>-Blood oxygenation level dependent (BOLD) response in SSM versus PI versus<br /><br>controls during oddball task and resting state; regression of BOLD response on<br /><br>latency and amplitude of ERP.<br /><br>-Resting state functional connectivity in SSM versus PI versus controls<br /><br>-Structural abnormalities in SSM versus PI versus controls, using voxel-based<br /><br>morphometry (VBM) to measure regional volumetry and diffusion tensor imaging<br /><br>(DTI) to measure structural connectivity<br /><br>-Cortical excitability as assessed using TMS.</p><br>