PET imaging of neuroinflammation in mild traumatic brain injury

Completed

• Conditions: mild traumatic brain injury; neurological disorder; 10029305

• Registration Number: NL-OMON38412
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

All subjects:
-Age above 18 and below 50 years.
-Written informed consent for participation.;Patients only:
-Diagnosis of mild traumatic brain injury.
-No abnormalities in the structural MRI during neurologist follow-up, 4-6 weeks after the injury.

Exclusion Criteria

All subjects:
-The use of benzodiazepines.
-The use of anticoagulants or having coagulation disorder.
-Use of somatic medication that may affect the immune system.
-Use of any investigational drug.
-Current or recent (<1 year) alcohol or substance abuse.
-Current or recent (<4 weeks) infectious or inflammatory disease.
-Current systemic disease.
-Major metabolic disease.
-Somatic, organic or neurological disorder (other than mTBI for patients).
-Participation in a scientific research study (<1 year) involving radiation.
-Claustrophobia.
-Presence of materials in the body that can be magnetized.;For healthy volunteers:
-Presence of infection of inflammation.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The [11C]-PK11195 binding potential in the brain, and the performance in the<br /><br>neuropsychological tests will be the primary parameters.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are white matter integrity, MRI Spectroscopy and<br /><br>serum proteins indicative of inflammation.</p><br>