Relationship Between Gestational Diabetes and Type 2 Diabetes

• Conditions: Gestational Diabetes; Type 2 Diabetes

• Registration Number: NCT01340924
• Lead Sponsor: Laval University

Brief Summary

The overall objective of this research project is to study the impact of preventive practices on the T2D-related risk profile among women with and without prior GDM and their children exposed and unexposed to GDM.

Detailed Description

Type 2 diabetes (T2D) is a growing public health problem owing to its prevalence as well as its high morbidity and mortality rates. The identification of high-risk populations is of great importance particularly because the onset of T2D can be prevented or delayed by lifestyle modifications. Among high-risk populations, women with previously diagnosed gestational diabetes mellitus (GDM) are at particularly high risk of developing T2D. The success in reducing the occurrence of T2D among women with previous GDM could be achieved only if appropriate preventive measures are undertaken. According to the American Diabetes Association (ADA) and the Canadian Diabetes Association (CDA), lifestyle modifications aimed at reducing body weight and increasing physical activity are recommended and women are encouraged to be breastfeeding their infants. Certain factors have been suggested as determinants of behavioral practices in women with prior GDM including cognitive and environmental factors. A better understanding of these issues is essential for developing effective preventive strategies and possibly reducing the prevalence of T2D in the population. Moreover, in utero exposure to maternal impaired glucose tolerance or diabetes may increase the risk of developing overweight or diabetes in offspring. Since March 2012 we thus test the presence of childhood metabolic alterations predictive of future T2D in GDM-exposed and unexposed offspring and investigate environmental factors during the postnatal period that are associated with prevention of metabolic alterations.

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2011-03-15
• Study First Submitted QC: 2011-04-21
• Study First Posted: 2011-04-25
• Primary Completion: 2016-09
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-07
• Last Update Posted: 2022-04-08
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 450

Inclusion Criteria

• Women aged ≥18 years with or without a diagnosis of GDM in the past 3-12 years and their children.

Exclusion Criteria

• Pregnant women, women with type 1 diabetes.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose tolerance assessed using a 75g-Oral Glucose Tolerance Test (OGTT) in mothers	1 year

Secondary Outcome Measures

Name	Time	Method
abdominal obesity	1 year	In mothers and children
Breastfeeding	1 year	In mothers and children
Physical activity	1 year	In mothers and children
metabolic syndrome	1 year	In mothers and children
Glycaemic and lipidic profile assessed using a fasting blood sample in children	1 year
overweight/obesity	1 year	In mothers and children
Nutrition	1 year	In mothers and children

Trial Locations

Locations (1)

Laval University, Institute of Nutraceuticals and Functional Foods; 🇨🇦 Quebec, Canada