Biochemical Approach to Measuring Surgical Trauma
Withdrawn
- Conditions
- Total Knee Replacement
- Registration Number
- NCT01037400
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Brief Summary
This study will examine the magnitude and time course of changes in circulating (serum and plasma) biomarker concentrations associated with musculoskeletal injury created by total knee replacement surgery. The sensitivity to injury will be characterized by the changes in mean serum concentration before and after surgery. Specificity for the injured state will be evaluated comparing the baseline to peak change (injury response) with the pre-surgery to follow-up baseline fluctuation (i.e. measurement noise).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity and Specificity of biomarkers in response to tissue injury 7 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
St. Joseph's Healthcare
🇨🇦Hamilton, Ontario, Canada