Lung Volume Change Between Noninvasive Positive Pressure Ventilation by Nasal Pillow and High Flow Nasal Cannula

Not Applicable

• Conditions: Respiratory Failure
• Interventions: Device: Nasal Pillow CPAP

• Registration Number: NCT02292992
• Lead Sponsor: Mackay Memorial Hospital

Brief Summary

The difference of lung volume change will be monitored by electrical impedance tomography before and after use of noninvasive positive pressure ventilation by nasal pillow and high flow nasal cannula in post-extubation patients.

Detailed Description

Electrical impedance tomography can effectively monitor the lung volume change in ICU patients who were under mechanical ventilator or noninvasive positive pressure ventilator support. Continuous positive airway pressure (CPAP) support by nasal pillow and high flow nasal cannula can improve inspiratory function in extubated patients . However, the extent of lung volume change or functional residual volume (FRC) change by using these two devices were never surveyed before in extubated patients. The investigators will check end-expiratory lung volume (EELV) ,anterior, medio-anterior, medio-posterior and posterior EELV by electrical impedance tomography after use of these two devices in extubated patients.

Study Timeline

• Study First Submitted: 2014-10-27
• Study First Submitted QC: 2014-11-13
• Study First Posted: 2014-11-18
• Status Verified: 2014-12
• Study Start: 2014-12
• Last Update Submitted: 2014-12-11
• Last Update Posted: 2014-12-15
• Primary Completion: 2015-10
• Study Completion: 2015-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• >20 y/o
• Any extubated patients after tolerating spontaneous breathing trial

Exclusion Criteria

• Presence of tracheostomy
• Recent facial trauma
• Active gastro-intestinal bleeding
• Do-not-intubate status and
• Planned use of BiPAP after extubation.
• Patients with unstable spinal lesions or fractures.
• BMI> 50
• Patients with a cardiac pacemaker
• Burn injury with skin defect

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Nasal pillow CPAP	Nasal Pillow CPAP	Nasal pillow CPAP

Primary Outcome Measures

Name	Time	Method
• End-expiratory lung volume (EELV) determined by electrical impedance tomography after high flow nasal cannula and nasal pillow CPAP	at day 1

Secondary Outcome Measures

Name	Time	Method
Anterior, medio-anterior, medio-posterior and posterior EELV at each time	at day 1

Trial Locations

Locations (1)

Mackay Memorial Hospital; 🇨🇳 Taipei, Taiwan