Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods.

Completed

• Conditions: Anesthesia
• Interventions: Other: Measurement of lung elastance by two methods

• Registration Number: NCT02830516
• Lead Sponsor: Stefan Lundin

Brief Summary

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

Detailed Description

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method in which a PEEP-step is performed with a size which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in anesthetized patients prior to major surgery.

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-06-21
• Study First Submitted QC: 2016-07-12
• Study First Posted: 2016-07-13
• Primary Completion: 2016-12-31
• Study Completion: 2016-12-31
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-05
• Last Update Posted: 2018-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Patient undergoing major surgery during anesthesia and muscle relaxation

Exclusion Criteria

• Patient with chronic obstructive lung disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Lung elastance - transpulmonary pressure	Measurement of lung elastance by two methods	Lung elastance and transpulmonary pressure measured by tidal esophageal pressure variations and by performing a PEEP step

Primary Outcome Measures

Name	Time	Method
Measurement of lung elastance	At 1 hour	Comparison of two method for measurements of lung elastance (Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume)

Trial Locations

Locations (1)

Sahlgrenska University Hospital; 🇸🇪 Gothenburg, Sweden