Comparative analgesic efficacy of pre-emptive oral clonidine and oral pregabalin in patients undergoing upper limb surgeries under supraclavicular block.A randomised,controlled prospective study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To study and compare block characteristics and rescue analgesic requirement with pre-emptive oral clonidine and oral pregabalin.
研究概览
简要总结
Study Title: Comparative analgesic efficacy of pre-emptive oral clonidine and oral pregabalin in patients undergoing upper limb surgeries under supraclavicular block: A randomized, controlled, prospective study.
Patients fulfilling the inclusion/exclusion criteria would be divided into three groups by block randomization and would receive clonidine 200mcg tablets, pregabalin 150mg tablets and placebo [colour matched B complex tablets] respectively. Patients will be assessed for a time duration of 24 hours for effect of pre-emptive oral clonidine and oral pregabalin on block characteristics (sensory motor onset and duration), post-operative rescue analgesic requirement, post-operative sedation and patient’s satisfaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Scheduled for upper limb surgeries under supraclavicular block.
- •ASA Grade I-II.
- •BMI 18.5-29.9.
排除标准
- •Patient’s refusal for block
- •Patients with known drug allergy to study
- •Patients who have taken analgesics 48hrs before
- •Use of antiepileptics drugs
- •Hepatic and renal pathologies affecting drug clearence
- •History of long term usage of NSAIDs and opioid analgesics
- •Patient in whom the block effect will be partial and will require supplementary analgesic
- •Diabetes mellitus and other neuropathic disorders
- •Any contraindications for peripheral nerve blocks
- •Coagulopathy disorders
- •Psychiatric disorders
- •Addiction to any drug.
结局指标
主要结局
To study and compare block characteristics and rescue analgesic requirement with pre-emptive oral clonidine and oral pregabalin.
时间窗: 24hours
次要结局
- To study and compare post-operative sedation and patient satisfaction.(24hours)