Comparing pain relieving efficacy of oral clonidine and oral pregabalin given pre-emptively to patients planned for upper limb surgeries under regional anesthesia

Not yet recruiting

• Conditions: Patients posted for upper limb surgeries under supraclavicular block having ASA Grade I-II.

• Registration Number: CTRI/2018/08/015353
• Lead Sponsor: Dr RPGMC Kangra at Tanda

Brief Summary

Study Title: Comparative analgesic efficacy of pre-emptive oral clonidine and oral pregabalin in patients undergoing upper limb surgeries under supraclavicular block: A randomized, controlled, prospective study.

Patients fulfilling the inclusion/exclusion criteria would be divided into three groups by block randomization and would receive clonidine 200mcg tablets, pregabalin 150mg tablets and placebo [colour matched B complex tablets] respectively. Patients will be assessed for a time duration of 24 hours for effect of pre-emptive oral clonidine and oral pregabalin on block characteristics (sensory motor onset and duration), post-operative rescue analgesic requirement, post-operative sedation and patient’s satisfaction.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2018-08-13
• Study Start: 2018-08-26

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1.Scheduled for upper limb surgeries under supraclavicular block.
• ASA Grade I-II.
• BMI 18.5-29.9.

Exclusion Criteria

• Patient’s refusal for block 2.
• Patients with known drug allergy to study 3.
• Patients who have taken analgesics 48hrs before 4.
• Use of antiepileptics drugs 5.
• Hepatic and renal pathologies affecting drug clearence 6.
• History of long term usage of NSAIDs and opioid analgesics 7.
• Patient in whom the block effect will be partial and will require supplementary analgesic 8.
• Diabetes mellitus and other neuropathic disorders 9.
• Any contraindications for peripheral nerve blocks 10.
• Coagulopathy disorders 11.
• Psychiatric disorders 12.
• Addiction to any drug.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study and compare block characteristics and rescue analgesic requirement with pre-emptive oral clonidine and oral pregabalin.	24hours

Secondary Outcome Measures

Name	Time	Method
To study and compare post-operative sedation and patient satisfaction.	24hours

Trial Locations

Locations (1)

Dr. Rajendra Prasad Government Medical College; 🇮🇳 Kangra, HIMACHAL PRADESH, India

Dr. Rajendra Prasad Government Medical College

🇮🇳Kangra, HIMACHAL PRADESH, India

Sheena Sharma

Principal investigator

7837985732

sharmasheena043@gmail.com