To assess the safety and feasibility of administering Dexamphetamine after stroke and its effect on cerebral and cardiac haemodynamics

Completed

• Conditions: Ischaemic Stroke; Circulatory System; Cerebral infarction

• Registration Number: ISRCTN36285333
• Lead Sponsor: niversity of Nottingham (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

1. Clinical stroke 3-30 days post ictus
2. Ischaemic stroke on computed tomography (CT)/magnetic resonance imaging (MRI)
3. Motor weakness (Motricity Index arm 0-99 inclusive)
4. Patients expected to stay in hospital for a further 8 days

Exclusion Criteria

1. Pre-morbid Barthel Index <12/20
2. Dementia
3. No enteral access in prescence of dysphagia
4. Moderate-severe hypertension (systolic blood pressure [BP] >160 or diastolic BP >100)
5. Clinical ischaemic heart disease, previous or current angina, myocardial infarction
6. Hyperexcitability or agitated states
7. Current hyperthyroidism
8. History of alcohol or drug abuse
9. Glaucoma
10. Predisposition to tics or Tourette Syndrome
11. Epilepsy or recent convulsions
12. Liver dysfunction (aspartate aminotransferase [AST] 3 x normal)
13. Renal dysfunction (creatinine >130)
14. Pregnancy and breastfeeding
15. Recent monoamine oxidase inhibitor (MAOI) usage
16. Porphyria

Study & Design

• Study Type: Interventional
• Study Design: Not specified