The effect of melatonin and N-acetyl cysteine on colistin-associated nephrotoxicity

Phase 3

• Conditions: Acute kidney failure.; Acute kidney failure, unspecified; N17.9

• Registration Number: IRCT20150221021159N3
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

Adult patients (more than 18 years) who received intravenous colistin.
Creatinine clearance = 45 ml/min at study recruitment
Oral tolerance to the drug

Exclusion Criteria

Receiving intravenous collistin or melatonin for at least 2 weeks before study recruitment
Acute kidney injury before study recruitment

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute kidney failure based on changes of urinary Neutrophil gelatinase-associated lipoccalin (NGAL) and serum creatinine levels. Timepoint: Measurement of urinary NGAL and serum creatinine at the initial of study (before initiation of colistin or intervention) and 5 days after intervention. Method of measurement: ELISA Kit.