A Single Case Study of Hypermetabolism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypermetabolism Due to Defect in Mitochondria
- Sponsor
- The Hospital for Sick Children
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- Brown/beige fat tissue distribution and activity. Measurement tool- 18F FDG PET/CT (fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
In the Metabolic Disorder clinic at The Hospital for Sick Children, the investigators identified a male, proband with possible Luft's disease. The investigators hypothesize that Luft's disease is caused by excess or dysregulation of brown/beige fat tissue.
To address the hypothesis, the investigators would like to assess brown fat distribution and activity in this subject.
Detailed Description
The subject will undergo a fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) at the Diagnostic Imaging unit of The Hospital for Sick Children.
Investigators
Andreas Schulze
Principal Investigator
The Hospital for Sick Children
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of hypermetabolism, possible Luft's disease.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Brown/beige fat tissue distribution and activity. Measurement tool- 18F FDG PET/CT (fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography)
Time Frame: 1 day
Areas of 18F-FDG uptake on PET colocalizing with regions of fat will be identified on CT (-250to -10 Hounsfield Units) and quantified by Standard Uptake Value (SUV).