Different PEEP Settings of COVID-19 Induced ARDS

Not Applicable

Completed

• Conditions: COVID-19; Mechanical Ventilation Pressure High; Acute Respiratory Distress Syndrome
• Interventions: Other: lung mechanics at different PEEP; Other: Gas exchanges at different PEEP; Other: Hemodynamics changes at different PEEP

• Registration Number: NCT04359251
• Lead Sponsor: Southeast University, China

Brief Summary

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Detailed Description

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Study Timeline

• Study Start: 2020-03-05
• Primary Completion: 2020-03-25
• Study Completion: 2020-03-25
• Status Verified: 2020-04
• Study First Submitted: 2020-04-13
• Study First Submitted QC: 2020-04-21
• Last Update Submitted: 2020-04-21
• Study First Posted: 2020-04-24
• Last Update Posted: 2020-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• COVID-19 patients with mechanical ventilation
• PO2/FIO2<300mmHg
• ages>18 years

Exclusion Criteria

• pneumothorax
• pregnant
• hemodynamics is unstable

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Optimizing compliance	lung mechanics at different PEEP	Best compliance during PEEP titration
Optimizing oxygenation	Gas exchanges at different PEEP	Best oxygenation during PEEP titration
ARDSnet	Hemodynamics changes at different PEEP	PEEP settings according to ARDSnet table

Primary Outcome Measures

Name	Time	Method
Respiratory system compliance improvement	20 minutes	the respiratory system compliance was compared among three groups

Secondary Outcome Measures

Name	Time	Method
Gas echanges improvement	20 minutes	P/Fwere compared among three groups

Trial Locations

Locations (1)

Zhongda Hospital, Southeast University; 🇨🇳 Nanjing, Jiangsu, China