Activation of the ileal brake by carbohydrates and plant extracts – A pilot study in ileostomy patients to develop sample collection and analytical methods

Not Applicable

Completed

• Conditions: This is a nutritional intervention study designed to assess the efficacy of a starch breakdown inhibitor and a glucoseuptake inhibitor present in natural plant extracts, on the oral delivery of carbohydrates to the ileum, in a group of ileostomy patients in whom it is possible to sample the contents of the ileum directly.; This is a nutritional intervention study designed to assess the efficacy of a starch breakdown inhibitor and a glucose; uptake inhibitor present in natural plant extracts, on the oral delivery of carbohydrates to the ileum, in a group of ileostomy patients in whom it is possible to sample the contents of the ileum directly.; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12614000382673
• Lead Sponsor: Plant and Food Research Ltd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-04-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

Patients who have undergone an end ileostomy procedure, where the large bowel has been removed but the small bowel remains healthy and intact
Procedure conducted more than 12 months previously, and currently stable
This may include patients with ulcerative colitis (UC)
Male or female, aged 20-79 years
BMI <40kg/m2
otherwise healthy

Exclusion Criteria

Patients who have undergone loop ileostomy
Crohn’s disease; celiac disease; diabetes mellitus (T1DM or T2DM)
Drug therapies that may alter small bowel transit, including non-steroidal inflammatory drugs (NSAIDs), antibiotics and proton pump inhibitors
Drug therapies that may interact with Acarbose (PrandaseTM, PrecoseTM)
Morbid obesity, BMI >40kg/m2
Any allergy to grape

Study & Design

• Study Type: Interventional
• Study Design: Not specified