Targeting the ileal brake – effects of carbohydrate (CHO) on hunger, satiety and energy intake

Not Applicable

Completed

• Conditions: Appetite regulation; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12612000429853
• Lead Sponsor: Foundation for Science and Research (FRST)Ministry of Science Innovation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-04-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

Male
Age 18-60 years
Lean, as defined by BMI <25kg/m2
Healthy, as ascertained by self-report and blood test

Exclusion Criteria

Overweight
Any medical conditions or medications known to affect appetite -related parameters, including depression
Low iron status, hence unsuitable for cannulation studies
Participation in an active diet program and/or loss/gain of >10% body weight within the last 6 months
Smoker or ex-smoker who quit within the last 6 months
Hypersensitivities or allergies to any foods or ingredients included in the study
Dislike and/or unwilling to consume items listed as study foods
Unwilling/unable to comply with study protocol
Participating in another clinical intervention trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale (VAS) scores for hunger and fullness.[Subjective ratings of satiety and nausea measured using visual analogue scales (VAS) at -120, -105, -90, -60, -30 & 0 (immediately before the test preload), 15, 30, 45, 60, 90, 120 (ad lib lunch), 150, 180, 240, 300, 360, 420 and 480 (ad lib dinner) and 510 minutes post preload.<br>t = 0 is the time that the infusion (treatment) begins]

Secondary Outcome Measures

Name	Time	Method
Energy Intake at ad libitum lunch meal. Energy, fat, carbohydrate (CHO) and protein intake will be calculated using the dietary program Foodworks Copyright (c) 1998-2007 Xyris Software.[Immediately post the ad libitum lunch, snack & dinner meals (t=150, t=255 and t=510)]