Effects of carbo-loading on the gastrointestinal microbiome

Recruiting

• Conditions: Ovarian cancer; C56; Malignant neoplasm of ovary

• Registration Number: DRKS00033976
• Lead Sponsor: niversitätsklinikum Heidelberg, Klinik für Frauenheilkunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

Ovarian carcinoma, exploratory laparotomy, consent to study

Exclusion Criteria

none

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the gastrointestinal microbiome compared between the groups using stool samples (analysis of 16S rRNA via next generation sequencing (NGS)) preoperatively, on day 3-5 after surgery and after 3 months.

Secondary Outcome Measures

Name	Time	Method
- Effects on patient outcome (parameters: occurrence and severity of postoperative complications (evaluation of clinical data, severity classification using the Clavien/Dindo classification), length of ICU stay, length of hospital stay)<br>- Effects on the immune system (leukocyte populations: analysis via flow cytometry preoperatively, as well as postoperatively on day 1, day 3-5 (depending on stool sample collection date) and after 3 months)