The effect of the short-term combined use of NSAIDs and diuretics/RAAS-inhibitors on the heart- and kidneyfunction in orthopaedic patiënts.
Phase 4
Completed
- Conditions
- heart failurehypertension1001928010023213
- Registration Number
- NL-OMON30017
- Lead Sponsor
- Heerenveen Ziekenhuis, De Tjongerschans
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
elective knee- or hipreplacement
combined use of RAAS-inhibitors and diuretics
Exclusion Criteria
Hip fracture with hipreplacement
Hospitalisation < 5 days
Revision of the knee or hip
Dementia
Nephrotoxic drugs
Interaction between other medication and the diuretics/NSAIDs/ACE-inhibitors/AT-II-antagonists
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>systolic en diastolic bloodpressure<br /><br>serum NT-proBNP<br /><br>Serum Creatinine<br /><br>Na+, K+, Mg2+, Ca2+<br /><br>Creatinine clearance<br /><br>Serum ureum</p><br>
- Secondary Outcome Measures
Name Time Method <p>Serum cystatin C</p><br>