Effects of a Cyclic NSAID Regimen on Levels of Prostaglandin-E2 and Interleukin-1beta in Gingival Crevicular Fluid of Subjects with Periodontitis: A Randomised Clinical Trial

Phase 2

Completed

• Conditions: Periodontitis; Non- surgical therapy; gingival crevicular fluid; periodontitis; anti- host modulation therapy; inflammatory agents; cytokines

• Registration Number: TCTR20160202001
• Lead Sponsor: Selcuk University&#44

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2004-01-08
• Study Start: 2016-02-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

Subjects were selected from a group of patients with moderate to chronic periodontal disease (at least two sites with loss of clinical attachment > 4mm and alveolar bone loss (ABL) of 30â€50%, as judged by radiography).(they had less than 16 teeth in their mouth, at least four of which had a probing depth (PD) greater or equal to 5 mm, and radiographic evidence of Alveoler bone loss). Subjects had received initial periodontal therapy, including scaling and root planning (SRP), as well as oral hygiene instruction less than six weeks before study commencement.

Exclusion Criteria

(i) no history of cardiovascular disease, renal disease, bleeding in the upper gastrointestinal tract, gastrointestinal ulcers, asthma, hypersensitivity to diclofenac or other NSAIDs, prosthetic joint replacement, or other chronic disease affecting compliance; (ii) had not received antibiotics or antibacterial agents less than 6 months before study commencement; (iii) had not received NSAIDs within 1 month, or phenytoin or calcium antagonists within 3 months; (iii) no history of pregnancy, lactation, or inadequate birth control;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diclofenac potassium 6 months biochemical aanlysis

Secondary Outcome Measures

Name	Time	Method
diclofenac potassium 6 months clinical paarmeters