Self-Management of Altered environmental Reactivity Training SCANning.

Conditions: Young people in the earliest phase of expression of psychopathology

Registration Number: NL-OMON24727

Lead Sponsor: Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 198

Inclusion Criteria

Two samples of adolescents / young adults aged 16-25 years with sub-diagnostic, subclinical stage 1b levels of depression and or psychosis (MADRS≥10 and/or CAPE≥12, and GAF<70, following the guidelines of McGorry et al [1] corresponding with approximately 15% of the general population) (n=132), fear (n=66), as well as a comparison group with no/low level of psychopathology (n=50) based on the rating-scores of psychopathology using questionnaires will be studied.

Exclusion Criteria

Exclusion criterion is receiving a current psychological or psychiatric treatment or significant need for care. Contra-indications for (f)MRI are use of pacemaker, metal implants, pregnancy or a history of claustrophobia. Past recovery from depression, psychosis or anxiety disorder is not an exclusion criterion as this would not impact the outcome measures.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
euroimaging effects:<br /><br>The primary outcome measure in the intervention study is the pre/post intervention change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward.<br /><br>The primary outcome measure in the observational study is the pre/post follow-up period change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward.

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes:<br /><br>1. Reward experience;<br /><br>2. Stress reactivity and salience reactivity as measured with ESM;<br /><br>3. Cross-sectional associations between fMRI and ESM and psychopathology. <br><br /><br /><br>Ancillary outcomes:<br /><br>Changes in depression, psychosis and fear psychopathology scores.