Effects of Intensive Statin Therapy on Left Ventricular Function for Patients With the First Acute Anterior Myocardial Infarction After Directly to Percutaneous Coronary Intervention.
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- left ventricular function
研究概览
简要总结
First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years of age
- •the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency PCI
- •informed consent
排除标准
- •Taking , or the need for long-term use of statins is greater than the initial dose
- •treated with PCI again within a mouth
- •active liver disease or liver dysfunction
- •the diagnosis of myopathy
- •severe renal insufficiency ( serum creatinine > 178umol / L )
- •Statin drug allergy or had a serious adverse reaction
- •severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease
- •malignancy or any other end-stage diseases result in a life expectancy of < 6 months
- •be participating in other clinical studies
- •not suitable for inclusion of the other cases
- •not treated with PCI
研究组 & 干预措施
standard group
patients in this group received standard statin treatment： Atorvastatin statins 20mg / night .
干预措施: standard group (Drug)
intensive group
patients in this group received intensive statin treatment： Admission atorvastatin statins the 80mg, after surgery，atorvastatin 40mg / night，and until 30 days after the operation , and thereafter 20mg / night .
干预措施: intensive group (Drug)
结局指标
主要结局
left ventricular function
时间窗: 30 days
ultrasonic observation of E/A
次要结局
- the left ventricular function(1 year)
- plasma brain natriuretic peptide(1 year)
研究者
Han Yaling, MD
vice president
Shenyang Northern Hospital