Safety and Efficacy of Dexmedetomidine vs Ketamine vs Midazolam Combined With Propofol in Gastrointestinal Procedures for Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Ramsy sedation score (RSS)
研究概览
简要总结
This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.
详细描述
Comparison between using intravenous (IV) propofol combined with either IV dexmedetomidine or IV ketamine or IV midazolam; to study the effect of their combination on level of sedation and hemodynamic stability on adult patients scheduled for gastrointestinal endoscopic procedures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients scheduled for gastrointestinal endoscopic procedures
- •≥ Age 18 years
排除标准
- •Allergy to any of the used drugs
- •impaired renal or liver functions
- •hypertensive patients
- •patients with cardiovascular
- •cerebrovascular disease
研究组 & 干预措施
dexmedetomidine
IV dexmedetomidine
干预措施: Dexmedetomidine (Drug)
ketamine
IV ketamine
干预措施: Ketamine (Drug)
Midazolam
IV midazolam
干预措施: Midazolam (Drug)
结局指标
主要结局
Ramsy sedation score (RSS)
时间窗: 3 to 6 months
time to achievement of Ramsy sedation score (RSS) 3-4, Ramsy sedation scale score from 1 to 6, 1 meaning anxious and 6 meaning no response to stimulus
次要结局
未报告次要终点
研究者
Walaa Youssef Elsabeeny
Lecturer of anesthesia and pain management
National Cancer Institute, Egypt