Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 主要终点
- Weight in grams of the pulmonary secretions
研究概览
简要总结
Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .
详细描述
Objective
To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In mechanical ventilation for a period of 24-72 h
- •End-expiratory pressure (PEEP) lower 10 cm of water.
- •Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.
排除标准
- •Pneumothorax and hemothorax undrained
- •Subcutaneous emphysema
- •Osteoporosis
- •Acute respiratory distress syndrome - (ARDS)
- •Fractures of ribs
- •Obese ( BMI greater than 35)
- •Mechanical ventilator with higher peak pressures 40 cm of water.
研究组 & 干预措施
Vibocompression (VB)
Grup 1 - Vibrocompression: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration
干预措施: Vibrocompression (VB) (Other)
Hyperinflation (HMV)
Grup 2 - Hyperinflation with Mechanical ventilator: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the increase in inspiratory pressure ventilator .
干预措施: Hyperinflation (HMV) (Other)
HMV+VB
Grup 3 - Hyperinflation with mechanical ventilator and vibrocompression:Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration and the increase in inspiratory pressure ventilator.
干预措施: HMV+VB (Other)
结局指标
主要结局
Weight in grams of the pulmonary secretions
时间窗: up to 24 weeks.
次要结局
- Peripheral oxygen saturation in percentage(up to 24 weeks)
- Tidal volume in milliliters(up to 24 weeks)
- Peak inspiratory pressure in centimeters of water(up to 24 weeks)
- Time mechanical ventilator (MV) in days(Through study completion, an average of 3 years.)
- Reintubation tracheal in percentage in the last 24 hours(Through study completion, an average of 3 years.)
- Heart Rate(up to 24 weeks.)
- Respiratory frequency(up to 24 weeks)
- Incidence of ventilator-associated pneumonia in percentage(Through study completion, an average of 3 years.)
- Mortality in the MV in percentage(Through study completion, an average of 3 years.)