Heart Rate Variability and Omega-3 Fatty Acid Status in Haemodialysis Patients: an Observational Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 3
- 主要终点
- Erythrocyte eicsapentaenoic acid (EPA) + docosahexaenoic acid (DHA) content (% weight of total fatty acids)
研究概览
简要总结
Studies suggest that dietary omega-3 fatty acids influence the extent to which the time interval between each heart beat varies (heart rate variability; HRV). Low HRV is associated with increased risk of sudden cardiac death (SCD). The purpose of this research is to investigate the relationship between 24 hour parameters of HRV and blood omega-3 fatty acid levels in patients who have recently commenced haemodialysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CKD stage 5 commencing haemodialysis,
- •male or female,
- •aged 40-80 y,
- •written informed consent
排除标准
- •history of chronic liver disease or neuropathy, infection or antibiotics within the last month.
结局指标
主要结局
Erythrocyte eicsapentaenoic acid (EPA) + docosahexaenoic acid (DHA) content (% weight of total fatty acids)
时间窗: 6-10 wk after commencing haemodialysis treatment
Primary independent variable
24 hour heart rate variability (Triangular index and SDNN)
时间窗: 6-10 weeks after commencing haemodialysis treatment
Primary dependent variables. Triangular index and SDNN are indicators of overall variability
次要结局
- 24 h heart rate variability - longer phase parameters(6-10 weeks after commencing haemodialysis)
- 24 h heart rate variability - short-phase parameters(6-10 weeks after commencing haemodialysis)
- Plasma EPA+DHA content (% weight of total fatty acids)(6-10 weeks after commencing haemodialysis6-10 weeks after commencing haemodialysis)
- Nocturnal heart rate variability - all parameters(6-10 weeks after commencing haemodialysis)
研究者
Dr Wendy Hall
Lecturer in Nutritional Sciences
King's College London