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临床试验/NCT03146832
NCT03146832已完成不适用

Exposure Works, But How? Testing Different Therapeutic Strategies During Exposure to Pain in an Experimental Design

Philipps University Marburg Medical Center2 个研究点 分布在 1 个国家目标入组 139 人开始时间: 2017年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
139
试验地点
2
主要终点
Pain tolerance

研究概览

简要总结

The goal of the present study is to compare different therapeutic strategies (according to habituation model vs. according to the inhibitory learning approach) during exposure to thermal pain in an experimental design.

详细描述

Exposure therapy is effective for the treatment of individuals with chronic pain and high levels of fear-avoidance. Nevertheless, mechanisms of change for exposure treatment are not sufficiently investigated. According to the habituation model, the activation of a fear structure leads to a habituation of the initial physical response. Therefore, the therapeutic recommendation is to focus on the reduction of fear during exposure sessions. According to the inhibitory learning approach, however, exposure experiences compete with the original US-CS fear association. Therefore, the therapist should maximize the violation of negative expectancies. The present study intends to compare both strategies during the exposure to pain in an experimental design.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

盲法说明

Participants were not aware which experimental condition they were allocated to.

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • female gender
  • sufficient knowledge of German language

排除标准

  • chronic and acute pain conditions
  • Raynaud's disease
  • high blood pressure
  • neuropathy, coronary diseases
  • diabetes, current alcohol
  • drug or pain-medication (last 24hours)

结局指标

主要结局

Pain tolerance

时间窗: 5 minutes prior and 5 minutes after three exposure practice trials

Determined by the temperature at which the participant stopped the heat stimulus

次要结局

  • Pain quality(5 minutes prior and 5 minutes after three exposure practice trials)
  • Pain Processing (Fragebogen zur Erfassung der Schmerzverarbeitung, FESV)(1-week prior and 10 minutes after three exposure practice trials)
  • Psychophysiological activation(throughout the experiment (5 minutes prior, during and 10 minutes after three exposure practice trails)
  • Pain intensity(5 minutes prior and 5 minutes after three exposure practice trials)
  • Pain Catastrophizing Scale (PCS)(1-week prior and 10 minutes after three exposure practice trials)
  • Pain Anxiety Symptom Scale (PASS)(1-week prior and 10 minutes after three exposure practice trials)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Julia Anna Glombiewski

Ph.D, Licensed Psychologist, Principal Investigator

Philipps University Marburg Medical Center

研究点 (2)

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