Patients With and Without Phonotrauma
- Conditions
- Phonotrauma
- Interventions
- Diagnostic Test: Acoustic voice analysisDiagnostic Test: High-speed videoendoscopy
- Registration Number
- NCT05625191
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Brief Summary
There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to varied phonation patterns, which will be addressed using the following two aims:
Aim 1: Determine how CPP and H1-H2 change as a function of using pressed voice production in individuals without laryngeal pathology.
Aim 2: Examine the sensitivity (minimally detectable change) and responsiveness (minimal clinically important difference) of CPP and H1-H2 to detect changes in different voice production conditions.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia)
- No history of or current voice disorder
- Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP).
- Atypical auditory-perceptual voice presentation
- History of voice disorder or laryngeal surgery.
Patient Group:
Inclusion Criteria:
- Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist.
- 18-65 years of age
Exclusion Criteria:
- Diagnosis of voice disorder not related to phonotrauma (e.g., vocal fold immobility, laryngeal dystonia, primary muscle tension dysphonia, etc.)
- Previous history of laryngeal surgery or voice therapy (to avoid confounding effects of previous treatment).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control Group- Without Phonotrauma Acoustic voice analysis Videoendoscopy and acoustic recordings using a head-mounted microphone with a voice-specialized SLP for participants without voice disorders, acoustic recordings will involve the five repetitions of three vowels (/ɑ, i, u/) and a standard reading passage (Rainbow Passage) in three voice conditions (breathy, typical, and pressed). For all participants, high-speed videoendoscopy and simultaneous acoustic recording will occur on one repetition of a sustained /i/ in each requested condition. Patients Diagnosed with Phonotrauma High-speed videoendoscopy Videoendoscopy and acoustic recordings using a head-mounted microphone with a voice-specialized SLP for Participants who have a diagnosis of phonotrauma will be instructed to produce five repetitions of the same three vowels but in only two conditions: typical voice and "resonant" voice following stimulability assessment and with cues. They will be instructed to maintain relatively consistent volume and pitch across conditions. For all participants, high-speed videoendoscopy and simultaneous acoustic recording will occur on one repetition of a sustained /i/ in each requested condition.
- Primary Outcome Measures
Name Time Method Cepstral Peak Prominence 1 year Cepstral peak prominence is a measure of the periodic energy of the acoustic voice signal.
The difference between the first and second harmonic (H1-H2) 1 year H1-H2 is a spectral measure derived from the acoustic voice signal that correlates with glottal configuration.
Average closing velocity 1 year Vocal fold closing phase velocity averaged across 100 vibratory cycles
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States