This study compares the effects of ketamine and etomidate on blood pressure and heart function during anesthesia induction in patients with decompensated shock.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- To evaluate and compare the changes in systolic blood pressure and heart rate before and after induction with ketamine versus etomidate in decompensated shock patients
研究概览
简要总结
Previous retrospective and prospective observation studies, randomized trials and meta-analysis have reported conflicting results. Some find that Ketamine is better and others report that there isn’t much difference between the two and few suggest that ketamine results in more hemodynamic instability. Paucity of study in Indian population exists and it’s underexplored in patients with shock. In practice there is a bias of using ketamine in high shock index patients, so with this study we try to decrease this bias and have equal chances of using ketamine or etomidate by randomisation. we will compare the peri-induction hemodynamic effects of ketamine and etomidate in patients with decompensated shock
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient more than 18 years undergoing emergency induction for intubation in emergency department Systolic blood pressure less than 90 mmhg.
排除标准
- •patient with known allergy to ketamine and etomidate Patient presenting as already intubated.
结局指标
主要结局
To evaluate and compare the changes in systolic blood pressure and heart rate before and after induction with ketamine versus etomidate in decompensated shock patients
时间窗: Time points in minutes - 0,5,10,15,30,45,60
次要结局
- To compare the need of additional vasopressor or change in the dose of existing vasopressor of ketamine group with etomidate group(Additional vasopressors required or not in the 1st 1 hour after induction)
研究者
Dr Dhruva Yadiyal
VMMC and Safdarjung Hospital