This study compares the effects of ketamine and etomidate on blood pressure and heart function during anesthesia induction in patients with decompensated shock.
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- VMMC and Safdarjung Hospital
- Enrollment
- 79
- Locations
- 1
- Primary Endpoint
- To evaluate and compare the changes in systolic blood pressure and heart rate before and after induction with ketamine versus etomidate in decompensated shock patients
Overview
Brief Summary
Previous retrospective and prospective observation studies, randomized trials and meta-analysis have reported conflicting results. Some find that Ketamine is better and others report that there isn’t much difference between the two and few suggest that ketamine results in more hemodynamic instability. Paucity of study in Indian population exists and it’s underexplored in patients with shock. In practice there is a bias of using ketamine in high shock index patients, so with this study we try to decrease this bias and have equal chances of using ketamine or etomidate by randomisation. we will compare the peri-induction hemodynamic effects of ketamine and etomidate in patients with decompensated shock
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patient more than 18 years undergoing emergency induction for intubation in emergency department Systolic blood pressure less than 90 mmhg.
Exclusion Criteria
- •patient with known allergy to ketamine and etomidate Patient presenting as already intubated.
Outcomes
Primary Outcomes
To evaluate and compare the changes in systolic blood pressure and heart rate before and after induction with ketamine versus etomidate in decompensated shock patients
Time Frame: Time points in minutes - 0,5,10,15,30,45,60
Secondary Outcomes
- To compare the need of additional vasopressor or change in the dose of existing vasopressor of ketamine group with etomidate group(Additional vasopressors required or not in the 1st 1 hour after induction)
Investigators
Dr Dhruva Yadiyal
VMMC and Safdarjung Hospital