Australasian Collaborative Trial of Vitamin C and Vitamin E supplementation for the prevention of pre-eclampsia

Completed

• Conditions: Pre-eclampsiaIntrauterine growth restriction; Pregnancy and Childbirth; Pre-eclampsia

• Registration Number: ISRCTN00416244
• Lead Sponsor: The University of Adelaide (Australia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-06-17
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 1877

Inclusion Criteria

All nulliparous women presenting to the antenatal clinic at the collaborating centre with a singleton pregnancy, between 14-22 weeks gestation, a normal blood pressure, and expected to give birth at the collaborating centre. Informed, written consent is necessary and there must be no contraindication to vitamin C or E therapy.

Exclusion Criteria

Women with any of the following: multiple pregnancy, life threatening fetal anomaly on ultrasound, known thrombophilia, chronic renal failure, hemochromatosis, women on heparin, warfarin or antihypertensive therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Incidence of small for gestational age infants<br>2. Clinical pre-eclampsia<br>3. Death or serious adverse pregnancy outcome for the infant

Secondary Outcome Measures

Name	Time	Method
Severe adverse outcomes for the woman up to six weeks postpartum.