Prediction of hypertensive disorder of pregnancy in first trimester using blood pressure,ultrasonography and pregnancy associated blood marker.
Not Applicable
- Conditions
- Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services
- Registration Number
- CTRI/2024/04/066044
- Lead Sponsor
- Bhaktivedanta Hospital and Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Pregnant females of age 18 to 45 years who are registered and planning to deliver at bhakti Vedanta hospital and willing for regular antenatal visits.
2. Willing to participate in study.
Exclusion Criteria
Patients with fetal chromosomal abnormality.
Patients diagnosed with multifetal pregnancy.
Patients having chronic hypertension or diagnosed with pre-eclampsia in previous pregnancy.
Patients having renal disease
obesity (BMI more than 40)
Autoimmune disorder like SLE
Not willing to participate in study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increased chances of development of pre-eclampsia are seen with PAPP-A values less than 0.5 MOM at 11 to 14 weeks,High mean arterial pressure increases the risk of pre-eclampsia, Abnormal uterine artery pulsatility index values have higher risk for development of pre-eclampsia. <br/ ><br>Timepoint: at 11 to 14 weeks, at 20 to 34 weeks, at the time of delivery
- Secondary Outcome Measures
Name Time Method Assessment of severity of pre-eclampsia using PAPP-A, mean arterial pressure and uterine artery pulsatility index values,Association of the time of development of pre-eclampsia i.e., early or late onset with PAPP-A values, mean arterial pressure and uterine artery pulsatility index,Correlation of fetal growth restriction with low PAPP-A values and high uterine artery pulsatility index,Evaluation of neonatal complications such as apgar score, birth weight and requirement of nicu admission in patients of pre-eclampsia <br/ ><br>Timepoint: at 11 to 14 weeks, at 20 to 34 weeks, at the time of delivery