RAdiotherapy With FDG-PET Guided Dose-PAINTing Compared With Standard Radiotherapy for Primary Head and Neck Cancer-3

Not Applicable

Recruiting

• Conditions: Head and Neck Cancer; Radiotherapy Side Effect

• Registration Number: NCT06297902
• Lead Sponsor: Oslo University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-2-12
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> 1. Histologically or cytologically verified invasive squamous cell carcinoma of the<br> head and neck region; Sinonasal cancer, oral cavity cancer, hypopharynx cancer,<br> larynx cancer, HPV negative oropharyngeal cancer and T4 (any N) HPV positive<br> oropharyngeal cancer.<br><br> 2. Patients planned for standard curative RT (with or without concomitant chemotherapy<br> [cisplatin, or cetuximab], with or without nimorazole hypoxic cell radiosensitizer)<br><br> 3. Age > 18 years<br><br> 4. WHO performance status 0-2<br><br> 5. Signed informed consent<br><br> 6. Ability to understand information about the study and to complete questionnaires<br><br>Exclusion Criteria:<br><br> 1. All diagnoses, cT1 cN0-N1 cM0<br><br> 2. Glottic cancer cT1-T2 cN0 cM0<br><br> 3. HPV positive oropharyngeal carcinoma T1-T3 (any N)<br><br> 4. Diabetes mellitus<br><br> 5. Use of anticoagulant medication<br><br> 6. Active smoking and/or alcohol abuse

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Late mucosal ulcer

Secondary Outcome Measures

Name	Time	Method
Early toxicity;Late toxicity;Odynophagia;Health-related quality of life