Comparison of different materials used for bone filling to improve gum health

Phase 3

Not yet recruiting

• Conditions: Chronic periodontitis,

• Registration Number: CTRI/2025/04/084507
• Lead Sponsor: Datta Meghe of Higher Education and Reasearch

Brief Summary

Periodontal regeneration is challenging because it requires the predictable regeneration of three very distinct and varied tissues (such as cementum, PDL, and bone) as well as a triphasic contact between them in order to guarantee the repair.The aim of this study is to compareand evaluate the effectiveness of amnioguard in combination with novabone puttyand A-PRF membrane in combination with novabone putty in the regeneration ofhuman periodontal intrabony defects using Cone Beam Computed Tomography(CBCT).  Twenty-four individuals in good systemic health will be treated with  novabone putty and autologous PRF (Group-A) f in combination with  amnioguard in combination with novabone putty  (Group-B) for twenty-four periodontal infrabony defects. Clinical and radiographic features will be evaluated before surgery and six months following the procedure. The final data will be subjected to statistical analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-01-08
• Last Update Posted: 2025-03-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• 1. Presence of at least 1 or 2 radiographically detectable interproximal infrabony osseous defect with probing depth 5mm and clinical attachment loss 5mm following initial therapy.
• 2)Depth of intraosseous component of the defect 3)A radiographic base of the defect at least 3mm coronal to the apex of the tooth.
• 4)Presence of at least 3mm width of keratinized gingiva around test teeth to allow complete soft tissue coverage of the defect.

Exclusion Criteria

• Patients who have undergone periodontal therapy in last 6 months.
• Patients who had received antibiotic therapy during the previous three months.
• Individuals who are expecting or who have allergies to the drugs in study.
• Pregnant ladies and lactating mothers .
• Regular users of mouthwash.
• Chronic alcoholics.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
months post-surgery.	6 months
Radiographic Bone Fill in Infrabony defects at 6	6 months

Secondary Outcome Measures

Name	Time	Method
1)Gain in Clinical Attachment Level(CAL)	2)Reduction in Probing Pocket Depth

Trial Locations

Locations (1)

Sharad Pawar Dental College; 🇮🇳 Wardha, MAHARASHTRA, India

Sharad Pawar Dental College

🇮🇳Wardha, MAHARASHTRA, India

Dr Geeta Jagdish Bhandari

Principal investigator

08237719188

gjb12286@gmail.com