DNI Values After Periodontal Treatment

Not Applicable

Completed

• Conditions: Inflammatory Response; Periodontal Inflammation; Periodontitis
• Interventions: Other: Only routine non-surgical periodontal treatment was applied to the patients.

• Registration Number: NCT05666622
• Lead Sponsor: Kahramanmaras Sutcu Imam University

Brief Summary

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Detailed Description

The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal disease has not been comprehensively documented. The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Study Timeline

• Study Start: 2020-10-01
• Primary Completion: 2021-07-01
• Study Completion: 2022-01-01
• Study First Submitted: 2022-12-09
• Study First Submitted QC: 2022-12-18
• Study First Posted: 2022-12-28
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-11
• Last Update Posted: 2024-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Patients diagnosed with periodontitis
• Patients have more than 20 teeth in the mouth
• Minimum age 18
• Maximum age 65

Exclusion Criteria

• Patients with any systemic disease
• Active smokers
• Pregnant or breastfeeding
• Patients have used any antibiotic or anti-inflammatory drug in the last 6 months
• Patients have received any periodontal treatment in the last 6 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Kahramanmaraş Sütçü İmam University	Only routine non-surgical periodontal treatment was applied to the patients.	Only routine non-surgical periodontal treatment was applied to the patients.

Primary Outcome Measures

Name	Time	Method
Changes in Delta Neutrophil Index values of periodontal treatment in patients with periodontitis.	12 weeks	We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment.

Secondary Outcome Measures

Name	Time	Method
Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.	12 weeks	We expect a decrease in the neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

Trial Locations

Locations (1)

Kahramanmaraş Sütçü İmam University; 🇹🇷 Kahramanmaraş, Turkey