The acute effects of dietary flavonoids and nitrate on blood pressure, endothelial function and nitric oxide (NO) status in healthy men and wome
- Conditions
- Cardiovascular diseaseCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12609000364279
- Lead Sponsor
- niversity of Western Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- All
- Target Recruitment
- 20
Healthy non smoking men and women
Exclusion criteria will include:
1. current or recent (<12 months) smoking
2. body mass index < 18 or > 35 kg/m2,
3. history of cardiovascular or peripheral vascular disease,
4. diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrations greater than or equal to 5.5 mmol/L,
5. a psychiatric illness,
6. other major illnesses such as cancer,
7. current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight),
8. reported lactating, pregnant or wishing to become pregnant during the study,
9. alcohol intake > 210 g per wk for women and > 280 g per wk for men, and
10. inability or unwillingness to consume foods/beverages provided.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean blood pressure between 2 and 6 hours after treatment measured using an automated blood pressure monitor[Blood pressure will be measured at baseline then every 20 minutes between 2 and 6 hours]
- Secondary Outcome Measures
Name Time Method Change in blood pressure over time (slope)[Between 1 and 3.5 hours after treatment with blood pressure measurements taken every 20 minutes];Endothelial function assessed by measuring flow mediated dilatation of the brachial artery[Baseline and 2.5 hours after treatment];Measures of nitric oxide status, including plasma s-nitrosothiols and nitrite and urinary nitrate concentrations[Baseline, and 2 hours and 4 hours after treatment]