Influence of bariatric surgery on NAFLD

Recruiting

• Conditions: E66.09; K75.8; Other specified inflammatory liver diseases

• Registration Number: DRKS00017085
• Lead Sponsor: Klinikum Nordstadt, Klinikum Region Hannover GmbHKlinik f. Allgemein-, Viszeral- und Gefäß- und Adipositas(AVGA)chirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 103

Inclusion Criteria

Primary elective bariatric operation
- Obesity with a BMI >35kg/m2 (obesity >II)
- Patient volunteers >=18 years of age and consentable

Exclusion Criteria

- Involvement in another study investigating NASH
- Alcohol abuse (> 20g/d for women, 40 g/d for men)
- Redo-operations
- Diabetes mellitus Typ 1
- Not willing to give informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is defined as the improvement of fibrosis (>1 degree of fibrosis) 1 and 3 years after bariatric surgery.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome is the histologic improvement of NASH (reduction of NAS>1), cardiovascular risk profile reduction, including blood pressure setting, anti-hypertensive and anti-diabetic co- medication, and the degree of obesity 1 and 3 years after bariatric surgery. Additionally, histologic measures are correlated with sonographic measures.