The Effect of Simulated Obstructive Apnoea and Hypopnoea on Heart Rhythm in Patients With Paroxysmal Atrial Fibrillation

Not Applicable

Completed

• Conditions: Patients With Paroxysmal Atrial Fibrillation
• Interventions: Other: Mueller manoeuvre; Other: Inspiratory threshold; Other: Expiratory apnoea; Other: Steady state normal breathing

• Registration Number: NCT01796080
• Lead Sponsor: University of Zurich

Brief Summary

In this randomised controlled cross-over study we will investigate whether intrathoracic pressure changes induced by simulated obstructive apnoea and hypopnoea trigger premature supraventricular and ventricular contractions as well as atrial fibrillation in patients with paroxysmal atrial fibrillation.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2013-02-18
• Study First Submitted QC: 2013-02-18
• Study First Posted: 2013-02-21
• Status Verified: 2013-12
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Last Update Submitted: 2013-12-20
• Last Update Posted: 2013-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Mueller manoeuvre	Mueller manoeuvre	Mueller manoeuvre lasting for 20 seconds
Inspiratory threshold	Inspiratory threshold	One continuous inspiration through an inspiratory threshold load for 20 seconds
Expiratory apnoea	Expiratory apnoea	Expiratory apnoea (without respiratory effort) lasting for 20 seconds
Steady state normal breathing	Steady state normal breathing	Steady state normal breathing for 20 seconds

Primary Outcome Measures

Name	Time	Method
Number of subjects with premature myocardial contractions and/or atrial fibrillation	20 seconds

Secondary Outcome Measures

Name	Time	Method
ECG-derived myocardial de- and repolarization times	20 seconds

Trial Locations

Locations (1)

University Hospital Zurich, Division of Pneumology; 🇨🇭 Zurich, ZH, Switzerland