The Effect of Simulated Obstructive Apnoea and Hypopnoea on Heart Rhythm in Patients With Paroxysmal Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Number of subjects with premature myocardial contractions and/or atrial fibrillation
研究概览
简要总结
In this randomised controlled cross-over study we will investigate whether intrathoracic pressure changes induced by simulated obstructive apnoea and hypopnoea trigger premature supraventricular and ventricular contractions as well as atrial fibrillation in patients with paroxysmal atrial fibrillation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-75 years
- •History of ECG-documented paroxysmal atrial fibrillation within the last 12 months and currently in sinus rhythm
- •Informed consent
排除标准
- •Mental or physical disability precluding informed consent or compliance with the protocol
- •Amiodarone or Dronedarone medication
- •Previous radiofrequency ablation for atrial fibrillation
- •Severe structural heart disease
研究组 & 干预措施
Mueller manoeuvre
Mueller manoeuvre lasting for 20 seconds
干预措施: Mueller manoeuvre (Other)
Inspiratory threshold
One continuous inspiration through an inspiratory threshold load for 20 seconds
干预措施: Inspiratory threshold (Other)
Expiratory apnoea
Expiratory apnoea (without respiratory effort) lasting for 20 seconds
干预措施: Expiratory apnoea (Other)
Steady state normal breathing
Steady state normal breathing for 20 seconds
干预措施: Steady state normal breathing (Other)
结局指标
主要结局
Number of subjects with premature myocardial contractions and/or atrial fibrillation
时间窗: 20 seconds
次要结局
- ECG-derived myocardial de- and repolarization times(20 seconds)