Estimation of Biomarkers in Crevicular Fluid around implants and its Correlation with bleeding on probing and probing depth

Not yet recruiting

• Conditions: Missing teeth with atleast one dental implant used for replacement

• Registration Number: CTRI/2019/01/017363
• Lead Sponsor: Dr Sheetal Jain

Brief Summary

This study aims to estimate Osteoprotegerin (OPG) levels in peri implant crevicular fluid and gingival crevicular fluid around implants and teeth in the same individual and its corelation with clinical parameters. A total of 60 PICF and GCF samples  will be collected from 15 patients at 3 and 5 months intervals after implant placement and OPG concentration will be analysed using ELISA. Clinical parameters such as bleeding on probing and probing depth will be evaluated and compared with OPG levels in PICF and GCF. The results will be analysed and compared using Wilcoxin signed rank test, McNemar’s test and Spearman’s corelation test.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-02
• Last Update Posted: 2019-01-31

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Age more than 18 years with good oral hygiene and atleast one dental implant, systemically healthy patients.

Exclusion Criteria

Patients with history of smoking, bruxism or any parafunctional habit.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate OPG levels from 3 months to 5 months	Evaluate OPG levels from 3 months to 5 months

Secondary Outcome Measures

Name	Time	Method
Evaluate OPG levels at 3 months after implant placement	3 months

Trial Locations

Locations (1)

Faculty of Dental Sciences, M. S. Ramaiah University of Applied Sciences; 🇮🇳 Bangalore, KARNATAKA, India

Faculty of Dental Sciences, M. S. Ramaiah University of Applied Sciences

🇮🇳Bangalore, KARNATAKA, India

Sheetal Jain

Principal investigator

9538913412

jainsheetal950@gmail.com